Mitochondrial DNA variations associated with recurrent pregnancy loss among Indian women

Ayyasamy Vanniarajan; Periyasamy Govindaraj; S Justin Carlus; Meka Aruna; P Aruna; Ajay Kumar; Richard Issac Jayakar; Anath C Lionel; Sandeep Gupta; Lakshmi Rao; Nalini J Gupta; Baidyanath Chakravarthy; Mamatha Deenadayal; Kamala Selvaraj; Sadaranga Andal; B Mohan Reddy; Lalji Singh; Kumarasamy Thangaraj

doi:10.1016/j.mito.2011.01.002

Mitochondrial DNA variations associated with recurrent pregnancy loss among Indian women

Mitochondrion. 2011 May;11(3):450-6. doi: 10.1016/j.mito.2011.01.002. Epub 2011 Feb 1.

Authors

Ayyasamy Vanniarajan¹, Periyasamy Govindaraj, S Justin Carlus, Meka Aruna, P Aruna, Ajay Kumar, Richard Issac Jayakar, Anath C Lionel, Sandeep Gupta, Lakshmi Rao, Nalini J Gupta, Baidyanath Chakravarthy, Mamatha Deenadayal, Kamala Selvaraj, Sadaranga Andal, B Mohan Reddy, Lalji Singh, Kumarasamy Thangaraj

Affiliation

¹ Centre for Cellular and Molecular Biology (CSIR), Hyderabad, India.

PMID: 21292039
DOI: 10.1016/j.mito.2011.01.002

Abstract

Several genetic factors have been found to be associated with recurrent pregnancy loss (RPL). However, not many attempts have been made to associate the mitochondrial DNA (mtDNA) variations with RPL. Therefore, we have analyzed the complete mtDNA of 100 women with RPL and 12 aborted fetal tissues. Our analysis revealed a total of 681 variations, most of which were in NADH Dehydrogenase (ND) genes that encode mitochondrial enzyme Complex I. Presence of T4216C variation (ND1 gene) in 9% of the RPL women and several pathogenic, and novel mutations suggest the role of mtDNA variations in RPL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abortion, Habitual / genetics*
Adult
DNA, Mitochondrial / genetics*
Electron Transport Complex I / genetics
Female
Gene Frequency
Humans
India
Mitochondrial Proteins / genetics
Polymorphism, Genetic*
Pregnancy

Substances

DNA, Mitochondrial
Mitochondrial Proteins
Electron Transport Complex I