Abstract
In this issue of Clinical Cancer Research, Zoglmeier and colleagues show that CpG, via the induction of IFN-α, matures myeloid-derived suppressor cells to abrogate immune suppression in 2 murine solid tumor models.
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / therapeutic use
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DNA / pharmacology*
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DNA / therapeutic use
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Humans
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Immune Tolerance*
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Immunotherapy
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Myeloid Cells / drug effects
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Myeloid Cells / immunology*
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Neoplasms / immunology
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Neoplasms / therapy*
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Oligodeoxyribonucleotides
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Toll-Like Receptor 9 / agonists*
Substances
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Antineoplastic Agents
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CpG ODN 1826
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Oligodeoxyribonucleotides
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Toll-Like Receptor 9
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DNA