Single-walled carbon nanotubes chemiresistor aptasensors for small molecules: picomolar level detection of adenosine triphosphate

Chem Commun (Camb). 2011 Apr 7;47(13):3793-5. doi: 10.1039/c0cc04733c. Epub 2011 Feb 2.

Abstract

Here we report single walled-carbon nanotubes (SWNTs)-based chemiresistor aptasensors for highly sensitive and selective detection of weakly or uncharged molecules using the displacement format. As a proof-of-concept we demonstrate the detection of ATP, a small weakly charged molecule, by displacement of the ssDNA anti-ATP aptamer hybridized to a small capture oligonucleotide covalently attached on SWNTs, with picomolar sensitivity and selectivity over GTP.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenosine Triphosphate / analysis*
  • Aptamers, Nucleotide / chemistry*
  • Biosensing Techniques / methods*
  • Nanotechnology
  • Nanotubes, Carbon / chemistry*
  • Sensitivity and Specificity

Substances

  • Aptamers, Nucleotide
  • Nanotubes, Carbon
  • Adenosine Triphosphate