Molecular recognition of ADP over ATP in aqueous solution by a polyammonium receptor containing a pyrimidine residue

Chem Commun (Camb). 2011 Mar 14;47(10):2814-6. doi: 10.1039/c0cc05054g. Epub 2011 Jan 31.

Abstract

The synergistic action of the different binding groups of the polyfunctional HL receptor leads to the recognition of ADP over ATP in water, with a selectivity coefficient of up to 116, a phenomenon which is unprecedented in the context of synthetic receptors in water. The recognition is mostly due to the good matching between H(3)L(2+) and the protonated forms of ADP.

MeSH terms

  • Adenosine Diphosphate / chemistry*
  • Adenosine Triphosphate / chemistry*
  • Models, Molecular
  • Molecular Conformation
  • Pyrimidines / chemistry*
  • Quaternary Ammonium Compounds / chemistry*
  • Solutions
  • Water / chemistry*

Substances

  • Pyrimidines
  • Quaternary Ammonium Compounds
  • Solutions
  • Water
  • Adenosine Diphosphate
  • Adenosine Triphosphate
  • pyrimidine