Congenital multiple pituitary hormone deficiency associated with hyperammonemia: a case report with a short review of the literature

H Inoue; K Ihara; M Ochiai; Y Takahata; H Kohno; T Hara

doi:10.1038/jp.2010.143

Congenital multiple pituitary hormone deficiency associated with hyperammonemia: a case report with a short review of the literature

J Perinatol. 2011 Feb;31(2):146-8. doi: 10.1038/jp.2010.143.

Authors

H Inoue¹, K Ihara, M Ochiai, Y Takahata, H Kohno, T Hara

Affiliation

¹ Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. hinoue@pediatr.med.kyushu-u.ac.jp

PMID: 21283082
DOI: 10.1038/jp.2010.143

Abstract

We herein report a case study of a female newborn with multiple pituitary hormone deficiencies who presented with generalized seizures, hypoglycemia and hyperammonemia at 18 h after birth. In addition, we review the association of hyperammonemia in neonates with multiple pituitary hormone deficiencies reported in the previous literature. This unrecognized association should be taken into account for the early diagnosis and treatment of these patients.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Drug Administration Schedule
Drug Monitoring
Female
Hormone Replacement Therapy
Humans
Hydrocortisone / administration & dosage*
Hydrocortisone / deficiency
Hyperammonemia / etiology*
Hypoglycemia / etiology
Hypopituitarism* / complications
Hypopituitarism* / congenital
Hypopituitarism* / diagnosis
Hypopituitarism* / metabolism
Hypopituitarism* / physiopathology
Hypopituitarism* / therapy
Infant, Newborn
Magnetic Resonance Imaging
Metabolic Networks and Pathways
Pituitary Gland* / abnormalities
Pituitary Gland* / metabolism
Pituitary Gland* / physiopathology
Seizures / etiology
Thyroxine / administration & dosage*
Thyroxine / deficiency
Treatment Outcome

Substances

Thyroxine
Hydrocortisone