Bacterial contamination of organ graft preservation solution and infection after transplantation

Transpl Infect Dis. 2011 Aug;13(4):331-4. doi: 10.1111/j.1399-3062.2010.00597.x. Epub 2011 Jan 31.

Abstract

Infectious complications represent a major cause of morbidity and mortality in patients with organ transplantation. Contamination of preservation solution (PS) can lead to life-threatening complications in the recipients. For a 3-year period, we investigated the bacterial contamination of both PSs and graft fragments, recipient infections, and explored the link between them. In total 137 organs were transplanted, and 131 organ and perfusate cultures out of 426 tested (30.8%) gave a positive bacterial culture, mainly with coagulase-negative staphylococci. Overall, 80 recipients out of 137 (58.4%) had at least 1 infection during the 4-month post-graft surveillance period. Twelve recipients had an infection with the same bacterial species that was recovered in the corresponding graft. However, based on pulsed-field gel electrophoresis typing results, only 1 case was very likely cross-transmitted via the transplantation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Infections / etiology*
  • Bacterial Infections / microbiology
  • Bacterial Infections / mortality
  • Drug Contamination*
  • Electrophoresis, Gel, Pulsed-Field
  • Gram-Negative Bacteria / classification
  • Gram-Negative Bacteria / genetics
  • Gram-Negative Bacteria / isolation & purification
  • Gram-Positive Bacteria / classification
  • Gram-Positive Bacteria / genetics
  • Gram-Positive Bacteria / isolation & purification
  • Humans
  • Kidney / microbiology
  • Liver / microbiology
  • Organ Preservation Solutions*
  • Organ Transplantation / adverse effects*
  • Transplants / microbiology*

Substances

  • Organ Preservation Solutions