Abstract
Bioassay-guided fractionation of the fruits of Piper longum afforded two new minor amides, piperlongimin A (2) [2E-N-isobutyl-hexadecenamide] and piperlongimin B (4) [2E-octadecenoylpiperidine] together with five known compounds with moderate cytotoxic activity. The structures were elucidated on the basis of spectroscopic evidences. All these compounds inhibited cell proliferation of human leukemia, HL-60 cell lines, and displayed major apoptosis-inducing effects.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemistry
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Amides / isolation & purification*
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Amides / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apoptosis / drug effects
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Fruit / chemistry*
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HL-60 Cells
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Humans
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India
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Piper nigrum / chemistry*
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Piperidines / chemistry
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Piperidines / isolation & purification*
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Piperidines / pharmacology*
Substances
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Amides
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Antineoplastic Agents, Phytogenic
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Piperidines
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piperlongimin A
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piperlongimin B