Two new amides with cytotoxic activity from the fruits of Piper longum

J Asian Nat Prod Res. 2011 Feb;13(2):143-8. doi: 10.1080/10286020.2010.546789.

Abstract

Bioassay-guided fractionation of the fruits of Piper longum afforded two new minor amides, piperlongimin A (2) [2E-N-isobutyl-hexadecenamide] and piperlongimin B (4) [2E-octadecenoylpiperidine] together with five known compounds with moderate cytotoxic activity. The structures were elucidated on the basis of spectroscopic evidences. All these compounds inhibited cell proliferation of human leukemia, HL-60 cell lines, and displayed major apoptosis-inducing effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry
  • Amides / isolation & purification*
  • Amides / pharmacology*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Apoptosis / drug effects
  • Fruit / chemistry*
  • HL-60 Cells
  • Humans
  • India
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Piper nigrum / chemistry*
  • Piperidines / chemistry
  • Piperidines / isolation & purification*
  • Piperidines / pharmacology*

Substances

  • Amides
  • Antineoplastic Agents, Phytogenic
  • Piperidines
  • piperlongimin A
  • piperlongimin B