Oxytocin does not modify GH, ACTH, cortisol and prolactin responses to Ghrelin in normal men

Vittorio Coiro; Riccardo Volpi; Adriano Stella; Simona Cataldo; Paolo Chiodera

doi:10.1016/j.npep.2010.12.007

Oxytocin does not modify GH, ACTH, cortisol and prolactin responses to Ghrelin in normal men

Neuropeptides. 2011 Apr;45(2):139-42. doi: 10.1016/j.npep.2010.12.007. Epub 2011 Jan 31.

Authors

Vittorio Coiro¹, Riccardo Volpi, Adriano Stella, Simona Cataldo, Paolo Chiodera

Affiliation

¹ Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy. vittorio.coiro@unipr.it

PMID: 21277631
DOI: 10.1016/j.npep.2010.12.007

Abstract

Background: In order to test the possible effect of Oxytocin (OT) on Ghrelin-stimulated GH, PRL, ACTH and cortisol, ten healthy normal men were studied.

Tests: Ghrelin (0.2 μg/kg body weight (BW)) as an iv bolus; Ghrelin plus OT (2 IU as bolus plus 0.07 IU/min administered for 90 min).

Results: The administration of OT did not change GH, PRL, ACTH and cortisol release induced by Ghrelin.

Conclusions: The data suggests that in humans OT did not modulate the GH, PRL, ACTH and cortisol response to Ghrelin.

MeSH terms

Adrenocorticotropic Hormone / metabolism*
Adult
Ghrelin / administration & dosage
Ghrelin / metabolism*
Human Growth Hormone / metabolism*
Humans
Hydrocortisone / metabolism*
Male
Oxytocin / administration & dosage
Oxytocin / metabolism*
Prolactin / metabolism*
Young Adult

Substances

Ghrelin
Human Growth Hormone
Oxytocin
Adrenocorticotropic Hormone
Prolactin
Hydrocortisone