Abstract
The term idiopathic short stature (ISS) refers to short children with no identifiable disorder of the growth hormone (GH)/insulin like growth factor (IGF) axis and no other endocrine, genetic or organ system disorder. This heterogeneous group of short children without GH deficiency (GHD) includes children with constitutional delay of growth and puberty, familial short stature, or both, as well as those with subtle cartilage and bone dysplasias. In rare cases, ISS is due to IGF molecular abnormalities. In this review we tackle the major challenges in the definition and treatment of ISS.
Keywords:
Idiopathic short stature; growth; growth hormone; insulin−like growth factor.
MeSH terms
-
Adolescent
-
Aromatase Inhibitors / therapeutic use
-
Body Height / drug effects
-
Child
-
Dwarfism / diagnosis
-
Dwarfism / drug therapy
-
Dwarfism / physiopathology
-
Dwarfism, Pituitary / diagnosis
-
Dwarfism, Pituitary / drug therapy
-
Dwarfism, Pituitary / physiopathology
-
Female
-
Gonadotropin-Releasing Hormone / analogs & derivatives
-
Gonadotropin-Releasing Hormone / therapeutic use
-
Growth Disorders / diagnosis*
-
Growth Disorders / drug therapy*
-
Growth Disorders / physiopathology
-
Human Growth Hormone / deficiency
-
Human Growth Hormone / therapeutic use
-
Humans
-
Male
-
Testosterone Congeners / therapeutic use
Substances
-
Aromatase Inhibitors
-
Testosterone Congeners
-
Human Growth Hormone
-
Gonadotropin-Releasing Hormone