Copper-free Sonogashira coupling of cyclopropyl iodides with terminal alkynes

Org Lett. 2011 Mar 4;13(5):956-9. doi: 10.1021/ol1029996. Epub 2011 Jan 26.

Abstract

The substrate scope of the copper-free Sonogashira coupling has been successfully extended to cyclopropyl iodides, allowing an efficient access to a wide variety of functionalized alkynyl cyclopropanes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemical synthesis*
  • Alkynes / chemistry*
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Copper / chemistry*
  • Cyclopropanes / chemical synthesis*
  • Cyclopropanes / chemistry*
  • Hydrocarbons, Iodinated / chemistry*
  • Molecular Structure
  • Palladium / chemistry

Substances

  • Alkynes
  • Cyclopropanes
  • Hydrocarbons, Iodinated
  • Palladium
  • Copper