Reductive alkylation of indoles with alkynes and hydrosilanes under indium catalysis

Org Lett. 2011 Mar 4;13(5):912-5. doi: 10.1021/ol1029673. Epub 2011 Jan 26.

Abstract

Under Indium catalysis, diverse alkylindoles were successfully prepared with a flexible combination of indoles and alkynes in the presence of hydrosilanes. In addition to the hydrosilane, carbon nucleophiles are also available. This new method generates alkylindoles in yields over 70% with a broad scope of functional group compatibility.

MeSH terms

  • Alkylation
  • Alkynes / chemistry*
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Indium / chemistry*
  • Indoles / chemical synthesis*
  • Indoles / chemistry*
  • Molecular Structure
  • Oxidation-Reduction
  • Silanes / chemistry*

Substances

  • Alkynes
  • Indoles
  • Silanes
  • Indium