Abstract
Most of the core components of the archaeal chromosomal DNA replication apparatus share significant protein sequence similarity with eukaryotic replication factors, making the Archaea an excellent model system for understanding the biology of chromosome replication in eukaryotes. The present review summarizes current knowledge of how the core components of the archaeal chromosome replication apparatus interact with one another to perform their essential functions.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Archaea / genetics*
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Archaea / metabolism*
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Archaeal Proteins / genetics
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Archaeal Proteins / metabolism*
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Chromosomes, Archaeal
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DNA Primase / metabolism
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DNA Replication*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Multiprotein Complexes / chemistry
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Multiprotein Complexes / metabolism
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Proliferating Cell Nuclear Antigen / metabolism
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Protein Interaction Mapping / methods
Substances
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Archaeal Proteins
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DNA-Binding Proteins
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Multiprotein Complexes
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Proliferating Cell Nuclear Antigen
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DNA Primase