Label-free DNAzyme-based fluorescing molecular switch for sensitive and selective detection of lead ions

Chem Commun (Camb). 2011 Mar 21;47(11):3099-101. doi: 10.1039/c0cc04523c. Epub 2011 Jan 24.

Abstract

We developed a label-free fluorescent Pb(2+) sensor utilizing a DNAzyme-based fluorescing molecular switch, which enables fluorescence detection of Pb(2+) in aqueous solution with high sensitivity and selectivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Circular Dichroism
  • DNA, Catalytic / chemistry*
  • DNA, Catalytic / metabolism
  • DNA, Single-Stranded / chemistry
  • Fluorescent Dyes / chemistry*
  • Ions / chemistry
  • Lead / analysis*
  • Organic Chemicals / chemistry
  • Spectrometry, Fluorescence / methods*

Substances

  • DNA, Catalytic
  • DNA, Single-Stranded
  • Fluorescent Dyes
  • Ions
  • Organic Chemicals
  • PicoGreen
  • Lead