Carbapenem resistance in Klebsiella pneumoniae due to the New Delhi Metallo-β-lactamase

Clin Infect Dis. 2011 Feb 15;52(4):481-4. doi: 10.1093/cid/ciq178.

Abstract

Carbapenem resistance in Klebsiella pneumoniae is most notably due to the K. pneumoniae carbapenemase (KPC) β-lactamase. In this report, we describe the occurrence of a newly described mechanism of carbapenem resistance, the NDM-1 β-lactamase, in a patient who received medical attention (but was not hospitalized) in India.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology*
  • Australia
  • Bacterial Typing Techniques
  • Carbapenems / pharmacology*
  • Female
  • Humans
  • India
  • Klebsiella Infections / microbiology
  • Klebsiella pneumoniae / classification
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / genetics
  • Klebsiella pneumoniae / isolation & purification
  • Microbial Sensitivity Tests
  • Multilocus Sequence Typing
  • Urinary Tract Infections / microbiology
  • beta-Lactam Resistance*
  • beta-Lactamases / biosynthesis*

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • beta-Lactamases
  • beta-lactamase NDM-1