Microtubule dynamics: Patronin, protector of the minus end

Curr Biol. 2011 Jan 25;21(2):R77-9. doi: 10.1016/j.cub.2010.12.011.

Abstract

It has long been surmised that cellular microtubules are capped at the minus ends to prevent their depolymerization. A recent study provides the first definitive identification of a minus-end-specific capping protein, termed Patronin, which protects the microtubule arrays of both mitotic and interphase cells.

MeSH terms

  • Animals
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism*
  • Evolution, Molecular
  • Gene Expression Regulation
  • Kinesins / metabolism
  • Microtubule-Associated Proteins / genetics
  • Microtubule-Associated Proteins / metabolism*
  • Microtubules / physiology*
  • Polymerization

Substances

  • Drosophila Proteins
  • Microtubule-Associated Proteins
  • patronin protein, Drosophila
  • Kinesins