Synthesis of egonol derivatives and their antimicrobial activities

Bioorg Med Chem. 2011 Feb 1;19(3):1179-88. doi: 10.1016/j.bmc.2010.12.044. Epub 2010 Dec 28.

Abstract

Eighteen derivatives of egonol (A-R) were synthesized and evaluated for their antimicrobial activities against Staphylococcus aureus ATCC 29213, Bacillus subtilis ATCC 6633, Candida albicans ATCC 10231 and Escherichia coli ATCC 8739 microorganisms comparing with egonol. The obtained data reported that compound B exhibited improved activities against all tested bacteria than egonol, others have shown different range of activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Antifungal Agents / chemical synthesis
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Bacillus subtilis / drug effects
  • Benzodioxoles / chemical synthesis*
  • Benzodioxoles / chemistry
  • Benzodioxoles / pharmacology
  • Benzofurans / analysis
  • Benzofurans / chemical synthesis*
  • Candida albicans / drug effects
  • Escherichia coli / drug effects
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Seeds
  • Staphylococcus aureus / drug effects
  • Structure-Activity Relationship
  • Styrax*
  • Sulfuric Acid Esters / chemical synthesis*
  • Sulfuric Acid Esters / chemistry
  • Sulfuric Acid Esters / pharmacology

Substances

  • 3-(2-(1,3-benzodioxol-5-yl)-7-methoxy-1-benzofuran-5-yl)propyl hydrogen sulfate
  • Anti-Bacterial Agents
  • Antifungal Agents
  • Benzodioxoles
  • Benzofurans
  • Sulfuric Acid Esters