Fast and flexible synthesis of pantothenic acid and CJ-15,801

Alan L Sewell; Mathew V J Villa; Mhairi Matheson; William G Whittingham; Rodolfo Marquez

doi:10.1021/ol103114w

Fast and flexible synthesis of pantothenic acid and CJ-15,801

Org Lett. 2011 Feb 18;13(4):800-3. doi: 10.1021/ol103114w. Epub 2011 Jan 20.

Authors

Alan L Sewell¹, Mathew V J Villa, Mhairi Matheson, William G Whittingham, Rodolfo Marquez

Affiliation

¹ WestCHEM, University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ, United Kingdom.

PMID: 21250753
DOI: 10.1021/ol103114w

Abstract

The fast and efficient syntheses of pantothenic acid and the antiparasitic agent CJ-15,801 have been achieved starting from a common imide unit through the selective manipulation of enamide intermediates.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Imides / chemistry*
Molecular Conformation
Molecular Structure
Pantothenic Acid / analogs & derivatives*
Pantothenic Acid / chemical synthesis*
Pantothenic Acid / chemistry
Pantothenic Acid / pharmacology
Plasmodium falciparum / drug effects
Stereoisomerism

Substances

CJ-15,801
Imides
Pantothenic Acid