This study demonstrates the feasibility of developing a medication list e-tool from multiple medication data sources that is accessible to patients, caregivers, and health care practices and is “portable” or accessible wherever patients go. A single medication list was created electronically by integrating data from the Shared Care Plan, a Web-based personal health record, and clinic electronic medical records (EMRs) to create a single, Web-based view. The feasibility of sharing accurate, updated information with everyone involved in a patient’s care was explored using innovative technology and training, while motivating health care professionals and patients to communicate medication regimen changes. Qualitative and quantitative evaluation methodologies were utilized to assess the impact of interventions among three outpatient clinic sites and 108 adult patients. Through extensive collaboration, clinic sites improved the accuracy of patient EMR medication lists, medication safety culture improved, and patients found the electronic medication list beneficial.