Abstract
A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 μg/mL, 8.3 μM).
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amphotericin B / pharmacology
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Candida albicans / drug effects
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Lactams, Macrocyclic / chemistry
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Lactams, Macrocyclic / isolation & purification*
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Lactams, Macrocyclic / pharmacology
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Microbial Sensitivity Tests
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Nuclear Magnetic Resonance, Biomolecular
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Polyenes / chemical synthesis*
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Polyenes / chemistry
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Polyenes / pharmacology
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Streptomyces / chemistry*
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Wasps / microbiology*
Substances
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Antifungal Agents
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Lactams, Macrocyclic
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Polyenes
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sceliphrolactam
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Amphotericin B