The giant cell tumor of the bone is a neoplastic low grade lesion that usually appears in the epiphyseal or metaphyseal region of the long bones. The lesion is usually solitary and becomes symptomatic when a considerable proportion of the bone has been destroyed. It is thought to represent approximately 19% of the benign bone tumors and 9% of all the primary bone tumors, according to a review by Schajowicz. The treatment of the giant cell tumor is controversial and the literature is confusing. The giant cell tumor is located mainly in the hand. Its potential aggressiveness makes us consider it in the differential diagnosis of the tumor lesions affecting the hand. The proposed treatment should try to preserve function to the extent possible but, at the same time, it needs to be radical enough to prevent a possible relapse. The purpose of this research work is to describe our experience with the treatment of the giant cell tumor in three cases that presented as a lytic, expansive lesion affecting the bones of the hand. They were treated with tumor resection and a bone graft to fill the defect. All three patients had a favorable course.