Gephyronic acid, a missing link between polyketide inhibitors of eukaryotic protein synthesis (part II): Total synthesis of gephyronic acid

Angew Chem Int Ed Engl. 2011 Jan 24;50(4):942-5. doi: 10.1002/anie.201005605. Epub 2010 Dec 29.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Fatty Acids, Monounsaturated / chemical synthesis
  • Fatty Acids, Monounsaturated / chemistry
  • Fatty Acids, Monounsaturated / pharmacology
  • Molecular Structure
  • Myxococcales / chemistry
  • Polyketide Synthases / antagonists & inhibitors*
  • Polyketide Synthases / metabolism
  • Protein Biosynthesis / drug effects*
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Enzyme Inhibitors
  • Fatty Acids, Monounsaturated
  • gephyronic acid
  • Polyketide Synthases