Abstract
An organocatalytic asymmetric direct vinylogous Michael addition of α,β-unsaturated γ-butyrolactam to enones has been achieved with a simple bifunctional thiourea-tertiary amine catalyst, affording the γ-substituted butyrolactam products with high diastereo- and enantioselectivity (up to >40:1 dr and 94-99% ee).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / chemistry*
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Catalysis
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Crystallography, X-Ray
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Ketones / chemical synthesis*
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Ketones / chemistry*
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Lactams / chemistry*
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Models, Molecular
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Molecular Structure
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Stereoisomerism
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Thiourea / chemistry*
Substances
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Amines
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Ketones
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Lactams
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Thiourea