Abstract
Two new lignans, palatiferin A (1) and palatiferin B (2), were isolated from the roots of Pseuderanthemum palatiferum, together with five known triterpenes, epifriedelanol (3), lupeol (4), lupenone (5), betulin (6), pomolic acid (7), and a dipeptide asperglaucide (8). Their structures were established from 2D NMR and mass spectroscopy. The absolute configuration of 1 and 2 was proposed based on the comparison of their optical rotation activities with those of compounds with similar structures such as wodeshiol and paulownin. The new lignans, palatiferin A (1) and palatiferin B (2) exhibited a moderate cytotoxicity against KB and HepG2 cell lines. However, betulin and lupeol, two abundant compounds from the roots of P. palatiferum, showed cytotoxic and antimicrobial activities.
© Georg Thieme Verlag KG Stuttgart · New York.
MeSH terms
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Acanthaceae / chemistry*
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Bacteria / drug effects
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Candida albicans / drug effects
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Cell Line, Tumor
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Humans
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology
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Medicine, East Asian Traditional
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Pentacyclic Triterpenes / chemistry
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Pentacyclic Triterpenes / isolation & purification
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Pentacyclic Triterpenes / pharmacology
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Plant Roots / chemistry
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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Anti-Infective Agents
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Antineoplastic Agents, Phytogenic
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Lignans
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Pentacyclic Triterpenes
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Triterpenes
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palatiferin A
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palatiferin B
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betulin
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lupeol