Abstract
Two new flavone derivatives (1 and 2) were isolated from the aerial parts of Macrothelypteris torresiana, along with four known flavonoids: protoapigenin, apigenin, kaempferol and quercetin. The structures were determined on the basis of spectroscopic data. Compound 1 showed weak cytotoxic activity against human tumour cell lines HepG₂ , MCF₇ and K562.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line, Tumor
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Cyclohexanones / chemistry*
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Cyclohexanones / isolation & purification*
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Cyclohexanones / pharmacology*
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Flavones / chemistry*
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Flavones / isolation & purification*
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Flavones / pharmacology*
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Neoplasms / drug therapy
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Neoplasms / pathology
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Plant Components, Aerial / chemistry*
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Polypodiaceae / chemistry*
Substances
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2-(cis-1,2-dihydroxy 4-oxo-cyclohex-5-enyl)-5,7-dihydroxychromone
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2-(trans-1,4-dihydroxy-cyclohexyl)-5,7-dihydroxychromone
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Antineoplastic Agents, Phytogenic
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Cyclohexanones
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Flavones