Isoswertisin flavones and other constituents from Peperomia obtusifolia

Nat Prod Res. 2011 Jan;25(1):1-7. doi: 10.1080/14786410903244954.

Abstract

A phytochemical investigation of the leaves and stems of Peperomia obtusifolia (Piperaceae) yielded a new flavone C-diglycoside isoswertisin-4'-methyl-ether-2''α-L-rhamnoside (1), along with four known compounds: isoswertisin-2''α-L-rhamnoside (2), (+)-diayangambin (3), 2-episesalatin (4) and corchoionoside C (5). The structures of the two flavone C-diglycosides (1, 2) were elucidated on the basis of 1D and 2D NMR spectroscopy and MS spectrometric data. These flavones were evaluated by bioautographic assay against Cladosporium cladosporioides and C. sphaerospermum and showed weak antifungal activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacokinetics
  • Cladosporium / drug effects
  • Flavones / chemistry
  • Flavones / isolation & purification*
  • Flavones / pharmacology
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Peperomia / chemistry*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Leaves / chemistry*
  • Plant Stems / chemistry*

Substances

  • Antifungal Agents
  • Flavones
  • Glycosides
  • Plant Extracts
  • isoswertisin-4'-methyl-ether-2''alpha-L-rhamnoside