Glucural (amigluracyl) improves survival of isolated rat hepatocytes in suspension

G A Sakuta; E V Baidyuk; M V Dobrogorskaya; A P Shiryaeva; A Ya Oksman; V I Morozov

doi:10.1007/s10517-011-1133-2

Glucural (amigluracyl) improves survival of isolated rat hepatocytes in suspension

Bull Exp Biol Med. 2011 Jan;150(3):324-6. doi: 10.1007/s10517-011-1133-2.

Authors

G A Sakuta¹, E V Baidyuk, M V Dobrogorskaya, A P Shiryaeva, A Ya Oksman, V I Morozov

Affiliation

¹ Institute of Cytology, the Russian Academy of Sciences, St. Petersburg, Russia. sakuta@yandex.ru

PMID: 21240345
DOI: 10.1007/s10517-011-1133-2

Abstract

Nonsteroid anti-inflammatory drug glucural (water-soluble N-methyl-D-glucosamine complex with 6-methyluracyl) improves survival of isolated rat hepatocytes stored in suspension. This effect of glucural is presumably explained by its membranotropism.

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Cell Survival / drug effects
Cytoprotection / drug effects*
Cytoprotection / physiology
Hepatocytes / drug effects*
Hepatocytes / physiology*
Oxygen Consumption / drug effects
Rats
Uracil / analogs & derivatives*
Uracil / pharmacology

Substances

Anti-Inflammatory Agents, Non-Steroidal
amigluracil
Uracil