Complete resolution of clozapine-induced sialorrhea with low dose trihexyphenidyl

Psychopharmacol Bull. 2010;43(4):73-5.

Abstract

Clozapine-induced sialorrhea (CIS) is a frequently occurring debilitating adverse effect. Although various treatment options exist, none has been proved to be distinctly superior to others. We report a case of CIS that responded to low dose of trihexyphenidyl (2 mg/day).

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antipsychotic Agents / adverse effects*
  • Clozapine / adverse effects*
  • Humans
  • Male
  • Muscarinic Antagonists / administration & dosage*
  • Sialorrhea / chemically induced
  • Sialorrhea / drug therapy*
  • Treatment Outcome
  • Trihexyphenidyl / administration & dosage*

Substances

  • Antipsychotic Agents
  • Muscarinic Antagonists
  • Trihexyphenidyl
  • Clozapine