A novel small molecule fluorescent sensor for Zn2+ based on pyridine-pyridone scaffold

Masayori Hagimori; Naoko Mizuyama; Yasuchika Yamaguchi; Hideo Saji; Yoshinori Tominaga

doi:10.1016/j.talanta.2010.12.003

A novel small molecule fluorescent sensor for Zn2+ based on pyridine-pyridone scaffold

Talanta. 2011 Feb 15;83(5):1730-5. doi: 10.1016/j.talanta.2010.12.003. Epub 2010 Dec 9.

Authors

Masayori Hagimori¹, Naoko Mizuyama, Yasuchika Yamaguchi, Hideo Saji, Yoshinori Tominaga

Affiliation

¹ Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Japan.

PMID: 21238776
DOI: 10.1016/j.talanta.2010.12.003

Abstract

The development of a water-soluble and small molecular weight fluorescent probe, 3-(4-methoxyphenyl)-4-(methylsulfanyl)-6-(pyridin-2-yl)pyridin-2(1H)-one (3), for detecting Zn(2+) based on pyridine-pyridone skeleton is reported. We observed a clear chelation enhanced fluorescence effect of 3 in the presence of Zn(2+). Other fluorescent properties of 3 are discussed.

MeSH terms

Chelating Agents / chemistry*
Fluorescent Dyes / chemical synthesis
Fluorescent Dyes / chemistry*
Molecular Structure
Pyridines / chemistry*
Pyridones / chemistry*
Solubility
Water / chemistry*
Zinc / chemistry*

Substances

Chelating Agents
Fluorescent Dyes
Pyridines
Pyridones
Water
Zinc