A new dimeric resveratrol from the roots of Shorea roxburghii

Winitra Patcharamun; Jirapast Sichaem; Pongpan Siripong; Suttira Khumkratok; Jonkolnee Jong-aramruang; Santi Tip-pyang

doi:10.1016/j.fitote.2011.01.003

A new dimeric resveratrol from the roots of Shorea roxburghii

Fitoterapia. 2011 Apr;82(3):489-92. doi: 10.1016/j.fitote.2011.01.003. Epub 2011 Jan 14.

Authors

Winitra Patcharamun¹, Jirapast Sichaem, Pongpan Siripong, Suttira Khumkratok, Jonkolnee Jong-aramruang, Santi Tip-pyang

Affiliation

¹ Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.

PMID: 21238549
DOI: 10.1016/j.fitote.2011.01.003

Abstract

A new resveratrol dimer, roxburghiol A (1) together with eleven known compounds were isolated from the roots of Shorea roxburghii. Their structures were identified on the basis of spectroscopic evidence and physicochemical properties. All isolated compounds were evaluated for their cytotoxicity (KB and HeLa cells). Compounds 8 and 9 showed potent cytotoxicity against both KB and HeLa cell lines with IC(50) values of 6.5, 8.5 and 8.7, 10.1 μg/mL, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Antineoplastic Agents, Phytogenic / therapeutic use
Dipterocarpaceae / chemistry*
HeLa Cells
Humans
Inhibitory Concentration 50
KB Cells
Molecular Structure
Neoplasms / drug therapy*
Phytotherapy*
Plant Extracts / chemistry*
Plant Extracts / pharmacology
Plant Extracts / therapeutic use
Plant Roots
Stilbenes / chemistry
Stilbenes / isolation & purification*
Stilbenes / pharmacology
Stilbenes / therapeutic use

Substances

Antineoplastic Agents, Phytogenic
Plant Extracts
Stilbenes
roxburghiol A