Efficient synthesis of new tetradentate ligands with potential applications for 64Cu PET-imaging

Ewen Bodio; Karine Julienne; Sébastien G Gouin; Alain Faivre-Chauvet; David Deniaud

doi:10.1016/j.bmcl.2010.12.072

Efficient synthesis of new tetradentate ligands with potential applications for 64Cu PET-imaging

Bioorg Med Chem Lett. 2011 Feb 1;21(3):924-7. doi: 10.1016/j.bmcl.2010.12.072. Epub 2010 Dec 19.

Authors

Ewen Bodio¹, Karine Julienne, Sébastien G Gouin, Alain Faivre-Chauvet, David Deniaud

Affiliation

¹ CNRS, UMR 6230, Université de Nantes, Chimie et Interdisciplinarité: Synthèse Analyse Modélisation, UFR Sciences et Techniques, Nantes, France.

PMID: 21236669
DOI: 10.1016/j.bmcl.2010.12.072

Abstract

We wish to report the synthesis of new tetradentate ligands in less than 3h in good to excellent yields from a commercially available compound using microwave-assisted technology. First tests of complexation showed a high ability of these ligands to chelate (64)Cu(II) in very diluted medium. These new systems have the potential to be used for nuclear medicine and particularly for PET-imaging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Copper / chemistry*
Copper Radioisotopes / chemistry
Hydrazines / chemical synthesis
Hydrazines / chemistry
Ligands*
Microwaves
Positron-Emission Tomography
Radiopharmaceuticals / chemical synthesis*
Radiopharmaceuticals / chemistry

Substances

Copper Radioisotopes
Hydrazines
Ligands
Radiopharmaceuticals
hydrazine
Copper