Haploidentical bone marrow transplantation in primary immune deficiency: stem cell selection and manipulation

David Hagin; Yair Reisner

doi:10.1016/j.hoc.2010.11.004

Haploidentical bone marrow transplantation in primary immune deficiency: stem cell selection and manipulation

Hematol Oncol Clin North Am. 2011 Feb;25(1):45-62. doi: 10.1016/j.hoc.2010.11.004.

Authors

David Hagin¹, Yair Reisner

Affiliation

¹ Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.

PMID: 21236389
DOI: 10.1016/j.hoc.2010.11.004

Abstract

Since the early 1980s T-cell depletion has allowed haploidentical bone marrow transplantation to be performed in patients with primary immunodeficiency for whom a matched sibling donor was not available, without causing severe graft versus host disease (GVHD). This review article presents the available data in the literature on survival, GVHD, and immune reconstitution in different categories of patients, with special emphasis on the impact of different T-cell depletion methods.