Abstract
Two new steroids (1 and 2) and the known pregna-1,4,20-trien-3-one (3) have been isolated from the Pacific octocoral Carijoa multiflora. Compound 1 possesses a novel spiropregnane-based steroidal skeleton. The photochemical transformation of 3 into 1 allowed the assignment of the absolute configuration at C-10 of 1. The antibacterial activities of compounds 1 and 3 were evaluated against a panel of bacterial strains.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Bacillus cereus / drug effects
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Enterococcus faecalis / drug effects
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Escherichia coli / drug effects
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Klebsiella pneumoniae / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Proteus mirabilis / drug effects
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Salmonella / drug effects
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Staphylococcus aureus / drug effects
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Steroids / chemistry
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Steroids / isolation & purification*
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Steroids / pharmacology
Substances
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Anti-Bacterial Agents
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Steroids
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carijodienone