Objective: To observe the effects of electroacupuncture (EA) of "Source-" + "Collateral-" acupoints ["Shenmen" (HT 7) + "Zhizheng"(SI 7)] and single acupoints "Neiguan"(PC 6) and HT 7 on cardiac function and myocardial enzymes in acute myocardial ischemia (AMI) rabbits.
Methods: Sixty Chinchilla rabbits were randomized into normal control, model, Shenmen (HT 7), Neiguan (PC 6), HT 7 + SI 7 groups, with 8 rabbits in each. AMI model was duplicated by occlusion of the anterior descending branch of left coronary artery under anesthesia. EA (2 Hz,1 mA) was applied to acupoints HT 7, PC 6,and HT 7 + SI 7 for 10 min. The maximum ascending rate (+ dp/dt max) and maximum descending rate (-dp/dt max) of the left ventricular pressure (LVP) were recorded by using PowerLab System. Serum lactate dehydrogenase (LDH) and creatine kinase MB (CK-MB) contents were detected with chromatometry.
Results: Serum LDH and OK-MB contents increased significantly in model group than in normal control group (P < 0.01). Compared with model group, serum LDH and CK-MB contents decreased remarkably in PC 6, HT 7 and HT 7 + SI 7 groups (P < 0.01, P < 0.05), and the effects of HT 7 + SI 7 group were significantly superior to those of PC 6 and HT 7 groups in lowering serum LDH and CK-MB levels (P < 0.01, P < 0.05). Compared with the normal control group, + dp/dt max lowered significantly and -dp/dt max increased markedly in the model group (P < 0.01), while compared with the model group, + dp/dt max increased obviously and -dp/dt max decreased significantly in the three EA groups (P < 0.01, P < 0.05). The effects of HT 7 + SI 7 group were markedly superior to those of HT 7 and PC 6 in raising + dp/dt max and lowering -dp/dt max (P < 0.05, P < 0.01), and those effects of PC 6 group were evidently better than those of HT 7 group (P < 0.05, P < 0.01).
Conclusion: EA of "Source-" + "Collateral-" aoupoints (HT 7 + SI 7), HT 7 and PC 6 has a positive effect in improving changes of cardiac function and in lowering serum LDH and CK-MB contents in AMI rabbits, and the effect of EA of HT 7 + SI 7 is superior to that of EA of single acupoint.