Steatocystoma simplex is a rare entity characterized by the presence of a solitary cutaneous cyst derived from a sebaceous duct or gland. Multiple locations of this lesion have been reported previously. The purpose of this article is to report the unusual presentation of steatocystoma simplex as an infratemporal fossa mass. To the best of our knowledge, no case of steatocystoma simplex at this site has been previously reported. We also describe the radiologic and pathologic features of this entity, which might aid in diagnosis and management, and we discuss its etiology and treatment options.