Vitamin D analogs 17,20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity

J Invest Dermatol. 2011 May;131(5):1167-9. doi: 10.1038/jid.2010.425. Epub 2011 Jan 13.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Bone Density / drug effects
  • Calcium / blood
  • Cells, Cultured
  • Cholecalciferol / administration & dosage
  • Cholecalciferol / analogs & derivatives*
  • Cholecalciferol / therapeutic use
  • Dermis / drug effects
  • Female
  • Fibroblast Growth Factor-23
  • Fibroblast Growth Factors / blood
  • Fibroblasts / drug effects*
  • Fibrosis / drug therapy
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Phosphates / blood
  • Vitamin D / analogs & derivatives*

Substances

  • 17,20-dihydroxypregnacalciferol-3,17,20-trihydroxy-9,10-secopregna-5,7,10-triene
  • Phosphates
  • Vitamin D
  • Cholecalciferol
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Calcium