Abstract
Gastric endocrine cell carcinoma is rare and associated with a poor prognosis. The first case was a man in his sixties with gastric endocrine cell carcinoma, of which a clinical finding was T2N1M0H1 (Stage IV). S-1 + CDDP therapy was selected and failed. CDDP+CPT-11 therapy was started and CT showed a partial response in ten months. But the tumor was re-grown and the patient died twenty months after diagnosis. The second case was a man in his seventies with gastric endocrine cell carcinoma, of which a clinical finding was T3N1M0H0P0, Stage IIIa, underwent total gastrectomy. Abdominal contrast-enhanced CT scan performed a month after the operation disclosed hepatic metastasis. After two months of S-1 regimen, CDDP + CPT-11 therapy was started.
MeSH terms
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Adenocarcinoma / pathology
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Adenocarcinoma / therapy
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Aged
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Camptothecin / administration & dosage
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Camptothecin / analogs & derivatives
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Cisplatin / administration & dosage
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Drug Combinations
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Endocrine Gland Neoplasms / pathology*
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Endocrine Gland Neoplasms / therapy
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Humans
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Irinotecan
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Male
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Middle Aged
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Oxonic Acid / administration & dosage
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Stomach Neoplasms / pathology*
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Stomach Neoplasms / therapy
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Tegafur / administration & dosage
Substances
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Antineoplastic Agents
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Antineoplastic Agents, Phytogenic
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Drug Combinations
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S 1 (combination)
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Tegafur
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Oxonic Acid
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Irinotecan
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Cisplatin
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Camptothecin