Synthesis and in vivo activity of some porphyrindione derivatives with potential in photodynamic therapy

J Photochem Photobiol B. 1990 Jun;6(1-2):133-41. doi: 10.1016/1011-1344(90)85082-8.

Abstract

A number of synthetic bacteriochlorins were prepared from porphyrindiones. The potential of these compounds as sensitizers for photodynamic therapy was examined using the FANFT-induced urothelial cell carcinoma (AY-27) transplanted into rats. In a number of cases, tumor regression was significant following treatment with both drug and light.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Photochemotherapy*
  • Porphyrins / chemical synthesis*
  • Porphyrins / therapeutic use
  • Radiation-Sensitizing Agents / chemical synthesis*
  • Rats
  • Rats, Inbred F344
  • Structure-Activity Relationship
  • Urinary Bladder Neoplasms / drug therapy*

Substances

  • Indicators and Reagents
  • Porphyrins
  • Radiation-Sensitizing Agents