Abstract
A number of synthetic bacteriochlorins were prepared from porphyrindiones. The potential of these compounds as sensitizers for photodynamic therapy was examined using the FANFT-induced urothelial cell carcinoma (AY-27) transplanted into rats. In a number of cases, tumor regression was significant following treatment with both drug and light.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Photochemotherapy*
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Porphyrins / chemical synthesis*
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Porphyrins / therapeutic use
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Radiation-Sensitizing Agents / chemical synthesis*
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Rats
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Rats, Inbred F344
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Structure-Activity Relationship
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Urinary Bladder Neoplasms / drug therapy*
Substances
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Indicators and Reagents
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Porphyrins
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Radiation-Sensitizing Agents