(-)-Sclerotiorin from an unidentified marine fungus as an anti-meiotic and anti-fungal agent

Nat Prod Commun. 2010 Nov;5(11):1789-92.

Abstract

(-)-Sclerotiorin, isolated and purified from the fermented broth of an unidentified marine fungus (98F134), inhibited the maturation of starfish oocytes induced by 1-methyl adenine with an IC50 value of 0.50 microM. (-)-Sclerotiorin also showed antifungal activity against Saccharomyces cerevisiae, Aspergilus fumigatus, Alternaria longipes, Piricularia oryzae, Verticillium albo-atrum, Fusarium culmorum, and F. nivale with IC50 values less than 20 microg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antifungal Agents / chemistry*
  • Antifungal Agents / pharmacology*
  • Benzopyrans / chemistry*
  • Benzopyrans / pharmacology*
  • Fungi / chemistry*
  • Fungi / drug effects
  • Meiosis / drug effects
  • Molecular Structure
  • Oocytes / drug effects
  • Starfish

Substances

  • Antifungal Agents
  • Benzopyrans
  • sclerotiorin