Abstract
Objective:
To investigate the effects of Bai-Chuan capsule (BC) on the left ventricular hypertrophy in spontaneously hypertensive rats (SHR).
Methods:
Taking SHR and Wistar Kyoto rats (WKY) as the model group and the control group respectively, Captopril as positive drug, administered BC 0.3 g/kg, Captopril 3.75 mg/kg or 0.5% CMC-Na to each group by ig for 3 months, and measured the change of blood pressure. The left ventricular mass index was calculated after rats were sacrificed. Left ventricle was used to pathological observations, plasma angiotensin II and aldosterone were measured by radioimmunoassay.
Conclusion:
BC can inhibit left ventricular hypertrophy, plasma level of angiotensin II and aldosterone to some extent in SHR.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldosterone / blood*
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Angiotensin II / blood*
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Animals
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Antihypertensive Agents / administration & dosage
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Antihypertensive Agents / pharmacology*
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Apiaceae / chemistry
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Blood Pressure / drug effects
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Capsules
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Captopril / pharmacology
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Drugs, Chinese Herbal / administration & dosage
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Drugs, Chinese Herbal / pharmacology*
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Heart Ventricles / drug effects
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Heart Ventricles / pathology
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Hypertension / blood
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Hypertension / drug therapy*
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Hypertrophy, Left Ventricular / blood
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Hypertrophy, Left Ventricular / drug therapy*
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Hypertrophy, Left Ventricular / prevention & control
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Male
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Myocardium / pathology
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Radioimmunoassay
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Random Allocation
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Rats
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Rats, Inbred SHR
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Rats, Inbred WKY
Substances
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Antihypertensive Agents
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Capsules
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Drugs, Chinese Herbal
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Angiotensin II
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Aldosterone
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Captopril