Hyaluronidase inhibitory rosmarinic acid derivatives from Meehania urticifolia

Toshihiro Murata; Toshio Miyase; Fumihiko Yoshizaki

doi:10.1248/cpb.59.88

Hyaluronidase inhibitory rosmarinic acid derivatives from Meehania urticifolia

Chem Pharm Bull (Tokyo). 2011;59(1):88-95. doi: 10.1248/cpb.59.88.

Authors

Toshihiro Murata¹, Toshio Miyase, Fumihiko Yoshizaki

Affiliation

¹ Department of Pharmacognosy, Tohoku Pharmaceutical University, Aoba-ku, Sendai, Japan. murata-t@tohoku-pharm.ac.jp

PMID: 21212553
DOI: 10.1248/cpb.59.88

Abstract

Nine new phenylpropanoids, rashomonic acids A-D (1-4) and meehaniosides A-E (5-9), along with four known compounds were isolated from Meehania urticifolia. The structure of each new compound was elucidated based on the results of spectroscopic analyses. Compounds 3-8 showed moderate hyaluronidase inhibitory activity with IC(50) values of 183-1049 µM.

MeSH terms

Cinnamates / chemistry*
Cinnamates / isolation & purification
Depsides / chemistry*
Depsides / isolation & purification
Hyaluronoglucosaminidase / antagonists & inhibitors*
Hyaluronoglucosaminidase / metabolism
Lamiaceae / chemistry*
Magnetic Resonance Spectroscopy
Molecular Conformation
Rosmarinic Acid

Substances

Cinnamates
Depsides
Hyaluronoglucosaminidase