This study investigated the specific contribution of occupations and work organization conditions to the onset and recurrent alcohol misuse in Canadian workers between 1994-1995 and 2002-2003. Longitudinal data were derived from Statistics Canada's National Population Health Survey, totaling 6,526 and 6,582 workers (45% females) nested in 1,337 and 1,413 neighborhoods for onset and recurrent alcohol misuse, respectively. Data were analyzed with multilevel logistic regression models. Results suggested a limited contribution for work factors to the onset of alcohol misuse, a stronger influence for them on recurrent alcohol misuse. The study's limitations are discussed.