Molecular targeting of neural cancer stem cells: TTAGGG, you're it!

Clin Cancer Res. 2011 Jan 1;17(1):3-5. doi: 10.1158/1078-0432.CCR-10-2686.

Abstract

Telomerase is an important mechanism by which cancers escape replicative senescence. In neural tumors, cancer stem cells express telomerase, suggesting that this may explain their preferential tumorigenesis. Oligonucleotide telomerase targeting selectively disrupts cancer stem cell growth through the induction of differentiation, adding to the armamentarium of anticancer stem cell therapies.

Publication types

  • Comment

MeSH terms

  • Animals
  • Glioma / therapy*
  • Humans
  • Neoplastic Stem Cells / metabolism*
  • Neural Stem Cells / metabolism*
  • Neuroblastoma / therapy*
  • Telomerase / antagonists & inhibitors*
  • Telomere / metabolism*

Substances

  • Telomerase