Abdominal mesotherapy injection extended the absorption of follicle-stimulating hormone

Chao-Chin Hsu; Hsin-Chih Kuo; Chao-Tien Hsu; Qing Gu

doi:10.1016/j.fertnstert.2010.12.007

Abdominal mesotherapy injection extended the absorption of follicle-stimulating hormone

Fertil Steril. 2011 May;95(6):2134-6, 2136.e1. doi: 10.1016/j.fertnstert.2010.12.007. Epub 2011 Jan 5.

Authors

Chao-Chin Hsu¹, Hsin-Chih Kuo, Chao-Tien Hsu, Qing Gu

Affiliation

¹ Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan. tube2363808@gmail.com

PMID: 21208615
DOI: 10.1016/j.fertnstert.2010.12.007

Abstract

Abdominal mesotherapy injection of recombinant human FSH (rhFSH) was well tolerated with increased net absorption (AUC0-∞ 4,655.3 IU·h/L and t1/2 247.6 h) up to 360 hours compared with those of 120 hours (AUC0-∞ 1,915.7 IU·h/L and t1/2 101.8 h). The extended absorption of rhFSH suggests that abdominal mesotherapy injection mode be considered for future administration of rhFSH in controlled ovarian hyperstimulation.

Publication types

Clinical Trial

MeSH terms

Abdominal Cavity
Adsorption
Adult
Area Under Curve
Female
Follicle Stimulating Hormone / administration & dosage*
Follicle Stimulating Hormone / blood
Follicle Stimulating Hormone / pharmacokinetics*
Gonadotropin-Releasing Hormone / administration & dosage
Gonadotropin-Releasing Hormone / agonists
Humans
Injections
Mesotherapy / methods*
Ovulation Induction / methods*
Pregnancy
Recombinant Proteins / administration & dosage
Recombinant Proteins / blood
Recombinant Proteins / pharmacokinetics
Time Factors
Young Adult

Substances

Recombinant Proteins
Gonadotropin-Releasing Hormone
Follicle Stimulating Hormone