Abstract
Four new nardosinane-type sesquiterpenoids, flavalins A-D (1-4), have been isolated from the Formosan soft coral Lemnalia flava. The structures of the new metabolites were determined by extensive spectroscopic analysis, and the structure of 2 was confirmed by X-ray diffraction analysis. A plausible biosynthetic pathway to 1 and 2 is proposed. Compound 1 was found to display dose-dependent inhibition of iNOS protein expression, and 1 and 2 were shown to possess significant neuroprotective activity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anthozoa / chemistry*
-
Crystallography, X-Ray
-
Cyclooxygenase 2 Inhibitors / chemistry
-
Cyclooxygenase 2 Inhibitors / isolation & purification*
-
Cyclooxygenase 2 Inhibitors / pharmacology
-
Lipopolysaccharides / pharmacology
-
Macrophages / drug effects
-
Mice
-
Molecular Conformation
-
Molecular Structure
-
Nitric Oxide / biosynthesis
-
Nitric Oxide Synthase Type II / drug effects
-
Nuclear Magnetic Resonance, Biomolecular
-
Sesquiterpenes / chemistry
-
Sesquiterpenes / isolation & purification*
-
Sesquiterpenes / pharmacology
Substances
-
Cyclooxygenase 2 Inhibitors
-
Lipopolysaccharides
-
Sesquiterpenes
-
flavalin A
-
flavalin B
-
Nitric Oxide
-
Nitric Oxide Synthase Type II