A novel Zn-catalyzed hydroamination of propargylamides: a general synthesis of di- and tri-substituted imidazoles

Chem Commun (Camb). 2011 Feb 21;47(7):2152-4. doi: 10.1039/c0cc04625f. Epub 2011 Jan 4.

Abstract

Starting from commercially available amines and propargylamides a variety of substituted imidazoles were synthesized via a novel hydroamination-cyclization sequence. The target compounds are obtained in good to excellent yields in the presence of catalytic amounts of zinc triflate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Amines / chemistry*
  • Catalysis
  • Cyclization
  • Imidazoles / chemical synthesis*
  • Imidazoles / chemistry
  • Mesylates / chemistry*

Substances

  • Amides
  • Amines
  • Imidazoles
  • Mesylates
  • trifluoromethanesulfonic acid