The organic mol-ecule of the title compound, C(16)H(12)N(6)O(2)·2H(2)O, lies across a crystallographic inversion centre. The dihedral angle between the pyrimidine and benzene rings is 80.78 (6)°. The two pyrimidine rings are parallel by virtue of the centre of symmetry. The pyrimidine and benzene rings form dihedral angles of 41.41 (7) and 40.26 (7)°, respectively, with the amide plane. The mol-ecules are linked by N-H⋯N and C-H⋯N hydrogen bonds into a two-dimensional network parallel to the (11) plane. O-H⋯O and C-H⋯O hydrogen bonds involving the water mol-ecules link the adjacent layers into a three-dimensional network. In addition, a C-H⋯π inter-action involving the benzene ring is observed.