In the mol-ecular structure of the title hydrazide derivative, C(18)H(26)N(4)O(4), the conformations of the two units of 2-(2,2-dimethyl-1-oxoprop-yl)hydrazide substituents are not planar; these two units are attached axially to the benzene ring with C(ortho)-C-C(=O)-N torsion angles of 28.1 (2) and 31.0 (2)° [where C(ortho) is the C atom at position 4 of the benzene ring relative to the substituent at position 3 or the C atom at position 6 of the benzene ring relative to the substituent at position 1, as appropriate]. The dihedral angles between the hydrazide units and the benzene ring are 62.66 (7) and 63.84 (7)°. In the crystal structure, mol-ecules are arranged in an anti-parallel manner and are linked by N-H⋯O inter-molecular hydrogen bonds and weak C-H⋯O inter-molecular inter-actions into a three-dimensional network. The structure is further stabilized by a weak C-H⋯N intra-molecular inter-action.