Abstract
Chemoprevention is one feasible approach to decreasing morbidity and mortality of non-small cell lung cancer (NSCLC). The present study aimed to explore the mechanisms of chemoprevention of NSCLC by Prunella vulgaris L. (PV) using a PV extract of 60% ethanol (P-60). In an A/J mouse model benzo[a]pyrene induction of lung tumors was significantly reduced difference by P-60 group. In addition, P-60 was found to have the ability to regulate cell cycle and induce apoptosis in SPC-A-1 cells. Therefore, we propose that P-60 has potential as a lung cancer chemopreventive agent.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apoptosis / drug effects*
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Benzopyrenes / pharmacology
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Carcinoma, Non-Small-Cell Lung / chemically induced
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Carcinoma, Non-Small-Cell Lung / drug therapy
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Carcinoma, Non-Small-Cell Lung / prevention & control*
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Cell Cycle / drug effects*
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Cell Line, Tumor
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Cell Proliferation
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Chemoprevention
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Disease Models, Animal
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Lung Neoplasms / chemically induced
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Lung Neoplasms / drug therapy
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Lung Neoplasms / prevention & control*
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Mice
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Mice, Inbred A
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Phytotherapy*
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Plant Extracts / therapeutic use*
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Prunella*
Substances
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Benzopyrenes
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Plant Extracts