Abstract
A key regulator of proliferation, differentiation and cell fate, the c-Myb transcription factor regulates the expression of hundreds of genes and is in turn regulated by numerous pathways and protein interactions. However, the most unique feature of c-Myb is that it can be converted into an oncogenic transforming protein through a few mutations that completely change its activity and specificity. The c-Myb protein is a myriad of interactions and activities rolled up in a protein that controls proliferation and differentiation in many different cell types. Here we discuss the background and recent progress that have led to a better understanding of this complex protein, and outline the questions that have yet to be answered.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Alternative Splicing / physiology
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Animals
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Cell Cycle Proteins / metabolism
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Cell Differentiation / drug effects
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Cell Proliferation / drug effects
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Cell Transformation, Viral / physiology
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DNA-Binding Proteins / metabolism
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Humans
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Leukemia / genetics
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MicroRNAs / physiology
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Neoplasms / genetics
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Neoplasms / physiopathology
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Oncogene Proteins v-myb / physiology*
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-myb / genetics
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Proto-Oncogene Proteins c-myb / physiology*
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Signal Transduction
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Stem Cells / drug effects
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Trans-Activators / metabolism
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Wnt Proteins / physiology
Substances
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Cell Cycle Proteins
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DNA-Binding Proteins
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MYBL1 protein, human
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MYBL2 protein, human
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MicroRNAs
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Oncogene Proteins v-myb
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-myb
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Trans-Activators
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Wnt Proteins