Abstract
B cells and antibodies are important elements of acquired humoral immunity in the fight against various pathogens, and signals through the B cell receptor (BCR) are crucial for the development, activation and differentiation of B cells. Our laboratory has focused on understanding the molecular mechanisms of BCR-mediated signaling cascades that regulate these processes in B cells. In this review, I will briefly present our studies that have clarified the molecular components of signaling cascades, mainly focusing on data using DT40 B cells and their genetic variants.
Copyright © 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Humans
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Lymphocyte Activation / genetics
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Lymphocyte Activation / immunology
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Mice
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Phosphatidylinositol 3-Kinases / immunology
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Phosphatidylinositol 3-Kinases / metabolism
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Phospholipase C gamma / immunology
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Phospholipase C gamma / metabolism
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Proto-Oncogene Proteins c-vav / immunology
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Proto-Oncogene Proteins c-vav / metabolism
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Receptors, Antigen, B-Cell / chemistry
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Receptors, Antigen, B-Cell / genetics
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Receptors, Antigen, B-Cell / immunology*
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Signal Transduction / genetics
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Signal Transduction / immunology*
Substances
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Proto-Oncogene Proteins c-vav
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Receptors, Antigen, B-Cell
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Phosphatidylinositol 3-Kinases
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Phospholipase C gamma